O le tagata muamua na fa'aaogaina le oloa o le sela CARsgenCAR-T e ausia ai le fa'amagaloga atoatoa

I le aso 10 o Fepuari, 2025, na faasilasila mai ai e le CARsgen Therapeutics o le tagata muamua na togafitia i le togafitiga allogeneic BCMA CAR-T na atiaeina i luga o le fausaga THANK-u Plus™, ua ausia le tali atoatoa (sCR) ma le itiiti ifo o le leaga o le faamai tumau (MRD) i le iloiloga o le Aso-28. Na atiaeina i totonu o le kamupani, o le fausaga THANK-u Plus™ o se tekinolosi allogeneic CAR-T fou ua mamanuina e foia ai luitau o le mafai ona maua i togafitiga CAR-T.

O le maʻi, na maua i le relapsed/refractory multiple myeloma, IgA-λ type (R-ISS Stage II), sa muamua faia ni togafitiga tuufaatasi se tolu faatasi ai ma le autologous hematopoietic stem cell transplantation. Ina ua maeʻa le alualu i luma o le faʻamaʻi ina ua maeʻa le togafitiga lata mai, sa lesitalaina le maʻi i le suʻega faafomaʻi. Ina ua maeʻa le tuiina o sela CAR T i le tulaga maualalo o le tui e tusa ai ma le faʻatulagaga faafomaʻi, na aʻafia ai le maʻi i le Grade 1 cytokine release syndrome (CRS), lea na pulea lelei i vailaʻau faʻaitiitia le fiva ma le tocilizumab, ma e leʻi faʻaalia e le maʻi le immune effector cell-associated neurotoxicity syndrome (ICANS) poʻo isi mea leaga e fesoʻotaʻi ma le CAR-T, ma faʻaalia ai se tulaga saogalemu lautele.

O lenei togafitiga CAR-T ua atiaʻe mo le togafitia o le relapsed/refractory multiple myeloma (R/R MM) ma le relapsed/refractory plasma cell leukemia (R/R PCL). O loʻo faʻamoemoeina nisi faʻafouga o faʻamatalaga i le afa lona lua o lenei tausaga.

I le taimi nei, o loʻo tele pea suʻega faafomaʻi o tekinolosi fou e teteʻe ai i le kanesa i Saina o loʻo sailia ai ni gasegase. Mo feutagaiga i vailaʻau ma tekinolosi fou, e mafai ona e faʻafesoʻotaʻi le Matagaluega Faʻavaomalo a le Falemaʻi Oncology a le Itumalo i Saute o Beijing.

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1.https://www.carsgen.com/cn/

2.https://www.prnasia.com/